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The academic value of internships: benefits across disciplines and student backgrounds
While student benefits from internship experience have been frequently documented in research, the emphasis has been on internship effects on employment and career indicators. This work is concerned with effects on academic outcomes and focuses on the robustness of such effects across academic disciplines as well as for different achievement levels of students, student gender, and ethnicity. We present findings from a longitudinal sample (n > 15,000) that covers an extensive range of subjects and disciplines for large Undergraduate cohorts. Main effects and interactions for student background characteristics were investigated showing stable academic benefits for advantaged and disadvantaged students. Further, using ordinal logistic multi-level modelling, we explored the impact on the probability of attaining a higher degree classification for different student scenarios, thus illustrating the practical significance of these internship effects. Effects are less likely to stem from maturation or self-selection. Findings are therefore discussed against a background of motivational approaches suitable to integrate both direct and indirect paths from internship experience to academic outcomes to career indicators
Preliminary Evidence That High-Dose Vitamin C has a Vascular Disrupting Action in Mice
High intravenous doses of vitamin C (ascorbic acid) have been reported to benefit cancer patients but the data are controversial and there is incomplete knowledge of what physiological mechanisms might be involved in any response. Vitamin C is taken up efficiently by cells expressing SVCT2 transporters and since vascular endothelial cells express SVCT2, we explored the hypothesis that administration of high dose vitamin C (up to 5 g/kg) to mice might affect vascular endothelial function. A single administration of vitamin C to mice induced time- and dose-dependent increases in plasma concentrations of the serotonin metabolite 5-hydroxyindole acetic acid (5-HIAA), a marker for vascular disrupting effects. Responses were comparable to those for the tumor vascular disrupting agents vadimezan and fosbretabulin. High-dose vitamin C administration decreased tumor serotonin concentrations, consistent with the release of serotonin from platelets and its metabolism to 5-HIAA. High-dose vitamin C also significantly increased the degree of hemorrhagic necrosis in tumors removed after 24 hours, and significantly decreased tumor volume after 2 days. However, the effect on tumor growth was temporary. The results support the concept that vitamin C at high dose increases endothelial permeability, allowing platelets to escape and release serotonin. Plasma 5-HIAA concentrations could provide a pharmacodynamic biomarker for vitamin C effects in clinical studies
Facial resemblance between women's partners and brothers
Research on optimal outbreeding describes the greater reproductive success experienced on average by couples who are neither too closely related, nor too genetically dissimilar. How is optimal outbreeding achieved? Faces that subtly resemble family members could present useful cues to a potential reproductive partner with an optimal level of genetic dissimilarity. Here, we present the first empirical data that heterosexual women select partners who resemble their brothers. Raters ranked the facial similarity between a woman's male partner, and that woman's brother compared to foils. In a multilevel ordinal logistic regression that modeled variability in both the stimuli and the raters, there was clear evidence for perceptual similarity in facial photographs of a woman's partner and her brother. That is, although siblings themselves are sexually aversive, sibling resemblance is not. The affective responses of disgust and attraction may be calibrated to distinguish close kin from individuals with some genetic dissimilarity during partner choice
Differences in the carcinogenic evaluation of glyphosate between the International Agency for Research on Cancer (IARC) and the European Food Safety Authority (EFSA)
The International Agency for Research on Cancer (IARC) Monographs Programme identifies chemicals, drugs, mixtures, occupational exposures, lifestyles and personal habits, and physical and biological agents that cause cancer in humans and has evaluated about 1000 agents since 1971. Monographs are written by ad hoc Working Groups (WGs) of international scientific experts over a period of about 12â
months ending in an eight-day meeting. The WG evaluates all of the publicly available scientific information on each substance and, through a transparent and rigorous process,1 decides on the degree to which the scientific evidence supports that substance\u27s potential to cause or not cause cancer in humans. For Monograph 112,2 17 expert scientists evaluated the carcinogenic hazard for four insecticides and the herbicide glyphosate.3 The WG concluded that the data for glyphosate meet the criteria for classification as a probable human carcinogen. The European Food Safety Authority (EFSA) is the primary agency of the European Union for risk assessments regarding food safety. In October 2015, EFSA reported4 on their evaluation of the Renewal Assessment Report5 (RAR) for glyphosate that was prepared by the Rapporteur Member State, the German Federal Institute for Risk Assessment (BfR). EFSA concluded that âglyphosate is unlikely to pose a carcinogenic hazard to humans and the evidence does not support classification with regard to its carcinogenic potentialâ. Addendum 1 (the BfR Addendum) of the RAR5 discusses the scientific rationale for differing from the IARC WG conclusion. Serious flaws in the scientific evaluation in the RAR incorrectly characterise the potential for a carcinogenic hazard from exposure to glyphosate. Since the RAR is the basis for the European Food Safety Agency (EFSA) conclusion,4 it is critical that these shortcomings are corrected
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